No. I have cookie set to remove on browser quit.

I use the BBC Homepage http://www.bbc.co.uk as my homepage. However, when Cookie is running, if I try to return to my homepage using the homepage button or type the address into the address bar, I get a page not found error.

If I shut down cookie and restart Firefox, I do not experience this issue.
I currently have no extensions installed and this is not a problem in Safari or Google Chrome. Nor does it seem to be a problem with other pages.